The Quantitative Musculoskeletal Imaging Group (Q-MIG) in the Radiology Department at Brigham and Women’s Hospital specializes in developing software image analysis methods to quantify structural changes related to musculoskeletal diseases. The primary focus is on osteoarthritis (OA) but we have substantial experience with rheumatoid arthritis (RA) and with various animal models to investigate more general disease processes. The overall goal of the program is to provide clinical researchers with fast and objective methods that can facilitate high-powered studies and clinical trials.